Relationship between Aberrant Expression of hMSH2 and Prognosis in Patients with Sporadic Colorectal Cancer

نویسندگان

  • Zhenqiang Sun
  • Xianbo Yu
  • Haijiang Wang
  • Zeliang Zhao
  • Ruiwei Xu
  • Shuo Zhang
  • Qisan Wang
  • Fa Fang
  • Xiaona Han
چکیده

1 Deparment of Gastrointestinal Surgery, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi 830011, Xinjiang, China 2 Infection & Statistical Office, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi 830011, Xinjiang, China 3 Department of Digestive Oncology, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi 830011, Xinjiang, China 4 Pathology Department, the Second Affiliated Hospital, Xinjiang Medical University, Urumqi 831100, Xinjiang, China 5 Molecule Genetic Lab, Cancer Research Institute, Central South University, Changsha 410078, Hunan, China. _____________________________________________________________________________________________ Article Information

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evaluation of the Relationship between Peroxisome Proliferator Receptors (PPARα, PPARγ, and PPARδ) Expression and Carcinoembryonic Antigen (CEA) in Patients with Colorectal Cancer

Introduction: Studies have shown that an increase in carcinoembryonic antigen (CEA) is associated with the progression of colorectal cancer and is considered a sensitive diagnostic factor for CRC. Moreover, the role of peroxisome proliferators (PPARs) has recently been considered in colorectal cancer. This study aimed to investigate the relationship between the expression level of PPARs and CEA...

متن کامل

Human mutL homolog 1 expression characteristic and prognostic effect on patients with sporadic colorectal cancer.

The aim of the present study was to analyze the relationship between aberrant human mutL homolog 1 (hMLH1) expression and clinicopathological parameters of patients with sporadic colorectal cancer, and to explore the prognostic effect of aberrant hMLH1 expression in these patients. The relationship was measured by chi-square test and Fisher's exact test. Survival analysis was performed with Kap...

متن کامل

Promoter hypermethylation of KLOTHO; an anti-senescence related gene in colorectal cancer patients of Kashmir valley

Hypermethylation of CpG islands located in the promoter regions of genes is a major event in the development of the majority of cancer types, due to the subsequent aberrant silencing of important tumor suppressor genes. KLOTHO; a novel gene associated primarily with suppressing senescence has been shown to contribute to tumorigenesis as a result of its impaired function. Recently the relevance ...

متن کامل

Clinical significance of mismatch repair gene expression in sporadic colorectal cancer

Mismatch repair (MMR) genes play an important role in the occurrence and development of sporadic colorectal cancer; however, the effect of MMR genes on clinicopathological features and prognosis remains unclear. The aim of the present study was to observe the clinical significance of MMR gene expression in sporadic colorectal cancer. Clinicopathological data and postoperative samples from 404 p...

متن کامل

The association between CD166 detection rate and clinicopathologic parameters of Patients with colorectal cancer

Background: Metastasis and recurrence of colorectal cancer after treatment is attributed to stem cells. The aim of this study was to determine the relationship between the expression of stem cell marker CD166 in colorectal cancer by immunohistochemistry and clinicopathologic parameters.Methods: From 2006 to 2012, 121 colectomy specimens of patients with colon cancer that were operated in Babol...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2014